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KMID : 0377619630050050551
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Korean Jungang Medical Journal
1963 Volume.5 No. 5 p.551 ~ p.575
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An Experimental study on the Influence of artificial Hemorrhage upon tissue Mast cell.
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Abstract
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Body weight 300 gm rats of both sexes were selected as materials. Through cardiac punctures one fourth of the total blood flow was aspirated. The rats were slaughtered 10 minutes, 30 m, 1 hour, 2 hours, 6 hours, 12 hours, 1 day, 2 days, 4 days, I week, 2 weeks, and 4 weeks after the aspiration of blood. The observation of mast cells in such organs as heart, lungs, trachea, esophagus, stomach, duodenum, small intestine, mesenterium, liver, spleen, kidneys, skin and uterus leads to the following conclusions :
1) The number of tissue mast cells in various organs of rats shows an acute decrease immediatly after the experimental major hemorrhage, reaching a minimum 10 minutes after the cardiac puncture. The number starts to be increased 30 m, after the puncture, arriving at a peak between the 6th and 24th hours, overpassing the normal values. The number of tissue mast cells are found to be gradually decreased after the said peak, approaching normal status around the 4th day after the aspiration of blood.
2) In case total number of tissue mast cells are increased, percentage of normal mast cells shows an increase, while that of diffused-type mast cells shows a decrease. In case total number of tissue mast cells are decreased, the former tends to be decreased, while the latter showing an increase,
3) No noticeable change has been observed regarding the histological distribution of tissue mast cells, Nor has there been any change observed as regards the perivascular and interstitial distribution of tissue mast cells;
4) The above result indicated that the distribution picture of tissue mast cells is keenly -susceptible to acute hemorrhage and the numbers and distribution follow a certain pattern, especially that the number of tissue mast cells are increased at a certain period after the hemorrhage, bypassing normal values.
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